The Department of Anesthesiology at the University of Texas Medical School at Houston
Department of Anesthesiology
The Department of Anesthesiology

Faculty Biography

Compassionate Care While You Sleep


Marie-Françoise Doursout, Ph.D.

Professor
Interim Vice-Chairman for Research

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Education and Post-Graduate Training

  • B.S.,  Eclole Superieure des Techniques de Biologie Appliquees, Paris, France
  • Ph.D. (with Honors), Ecole Pratique des Hautes Etudes, Paris, France

Professional Experience

  • Assistant Professor, Pharmacology, Director, Cardiovascular Research Lab, Baylor College of Medicine, Houston, Texas, 1987-1989
  • Assistant Professor, Department of Anesthesiology, The University of Texas Medical School at Houston, Houston, Texas, 1989-1991
  • Assistant Professor, Department of Anesthesiology, The University of Texas Medical School at Houston, Houston, Texas, 1991-1997
  • Associate Professor, Department of Anesthesiology, The University of Texas Medical School at Houston, Houston, Texas, 1997-2009
  • Professor, Department of Anesthesiology, The University of Texas Medical School at Houston, Houston, Texas, 2009-Present
  • Interim Vice Chairman for Research, Department of Anesthesiology, The University of Texas Medical School at Houston, Houston, Texas, 2009-Present

Professional Organizations

  • American Society of Anesthesiology
  • Texas Society of Anesthesiologists
  • American Heart Association:  Circulation Research
  • Critical Care Medicine

Scientific Journal Reviewer

  • Journal of Pharmacology and Experimental Therapeutics
  • Journal of Cardiovascular Pharmacology
  • American Journal of Physiology
  • Perfusion Journal
  • Biochemical Pharmacology Journal
  • Journal of Critical Care
  • Anesthesiology
  • Vascular Health and Risk Management

Grant Reviewer

Consultant

  • NASA/Krug Life Sciences: Physiological Research Laboratories Group Responsibilities included cardiovascular monitoring test subjects undergoing microgravity, 1993 – 1996.

Grant Support

  • Co-P.I.:  Cardiovascular Outcomes of the Corrin-Mediated Activation of Soluble Guanylyl-Cyclase, American Heart Texas Affiliate, 2009-2011
  • P.I.:  Role of the Microenvironment on Cardiovascular Function in Rats Exposed to Ionizing Radiation., TATRC (ARMY), 2009-2010
  • P.I.:  The University of Texas Health Science Center at Houston’s Grants 102 Program Mentoring Award, 2009
  • P.I.:   A Comparative in Vivo Study of Local Neurotoxicity of 2- Chloroprocaine, Lidocaine and Bupivacaine in Rats, Sintetica Pharmaceuticals, 2006-2009
  • Co-P.I.:  Texas Training and Technology against Trauma and Terrorism, Army, 2006-2008
  • Co-P.I.:  A Soluble Guanylyl Cyclase Mouse Knock-Out Model, NSBRI, 2002-2006
  • Collaborator:  Ultrasonic Instrumentation for Cardiovascular Studies, National Institutes of Health, 2000-2007
  • P.I.:  Lung Function in Prolonged Heart Failure, National Institutes of Health, 2000-2007

Selected Publications

  1. Doursout MF, Patil S, Kozar R, Deng XI, Ko T, Holcomb J:  Assessment of endothelium integrity in hemorrhaged and/or resuscitated rats.  Shock, 2011.
  2. Doursout MF, Martin E, Garg H, Bryan N, Conyers JL, Sharina IG:  Total body irradiation affects the integrity of nitric oxide/cGMP signaling in rat tissues.  J FASEB 2011.
  3. Doursout  MF, Sharina I, Liang YY, Conyers J, Murad F: Role of oxidative  stress in irradiated rats.  Anesthesiology, 2010.
  4. Deng X, Cao Y, Doursout MF, He G, Kozar RA, Holcomb JB, Ko TC:  Standard storage of fresh plasma (FFP) reduces its anti-apoptotic effects during hemorrhagic shock (HS) resuscitation. Shock 33: S1:P119, 2010.
  5. Alrehami N, Matijevic N, Doursout MF, Dong JF, Cruz MA, Holcomb JB and Vijayan KV.  Regulation of protein phosphatas 2B activity and the exocytosis of von willebrand factor in hemorrhagic shock. Shock 33: S1:P118, 2010.
  6. Pati S, Doursout MF, Holcomb JB:  Human mesenchymal stem cells inhibit inflammation and preserve vascular integrity in lungs after hemorrhage shock.  Shock 33: S1: P91, 2010.
  7. Doursout MF, Liang YY, Deng X, Cao Y, Salbury J, Ko T, Conyers J and J. Holcomb.  Plasma resuscitation suppresses reactive oxygen species production in hemorrahged rats.  Shock 33: S1: P91, 2010.
  8. Bick R, Bick DL, Doursout MF, Schurdell MS, Young LM, Osuagwu UC, Poindexter BJ: A rat lipopolysaccharide model for parkinson's disease neurodegeneration: inflammatory cells and cytokines in brain tissue. 2nd World Parkinson’s Congress, 2010.
  9. Doursout MF, Sharina I, Martin E, Murad F: Hypertension and cardiovascular diseases: updates on nitric oxide.  Curr Hypertens Rev  6(4):232-237, 2010.
  10. Pati S, Matijevic N, Doursout MF, Ko T, Cao Y, Deng X, Gonzalez E, Dong JF, Kozar RA, Hartwell E, Conyers J, Holcomb JB: Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw.  J Trauma 1:S55-63, 2010.
  11. Martin E, Sharina IG, Liang YY, Doursout MF: Corrin-mediated activation of nitric oxide receptor and its cardiovascular consequences. Circulation, 120: S1072, 2009.
  12. Doursout M, Liang Y, Partha R, Pati S, Cattano D, Conyers J, Holcomb J:  Effects of L-NAME and TPCK on nitric oxide production in hemorrhaged rats.  Shock 31(S):49, P87, 2009.
  13. Holcomb J, Gerber M, Kozar R, Parthasarthy R, Matijevic N, Doursout MF, Ko T, Hartwell B, Conyers J, Pati S:  Protective effects of plasma (FFP) on pulmonary and lympathatic endothelial permeability diminishes between day 0 through day 5 after thaw.  Shock 31(S):52, P97, 2009.
  14. Doursout MF, Liang YY, Pati S, Matijevic N, Holcomb:  Role of the NF-кB pathway in rats subjected to moderate hemorrhage.  J FASEB, 2009.
  15. Cattano D, Liang Y, Doursout MF: Left heart failure induces progressive lung dysfunction and initiates pulmonary fibrosis. American Society of Clinical Investigation/Association American Physicians, #61, 2009.
  16. Doursout MF, Sharina I, Sharine V, Murad F: Role of sGC isoforms in sepsis-induced organ dysfunction in rats.  J Crit Care 35:12, 212, 2008.
  17. Doursout MF, Oguchi T, Liang YY, Hartley CJ, Chelly B, Chelly JE:  Distribution of nitric oxide synthase isoforms in a porcine endotoxin shock model. Shock 29: 6; 692-702, 2008.
  18. Bick RJ, Poindexter BJ, Kott MM, Liang YY, Dinh KT, Stimming EF, Bick DL, Doursout MF, Schiess M: Cytokine disrupts intracelluclar patterns of Parkinson’s disease associated proteins alpha-synuclein, tau and ubiquitun in cultured glia cells. Brain Res 1217:2003-212, 2008.
  19. Bian K, Doursout MF, Ferid M: Vascular system, role of nitric oxide in cardiovascular disease. J Clin Hypertens (Greenwich). 10(4):304-10. 2008.
  20. Doursout MF, Liang YY, Sharina IG, Sharin VG, Murad F: Protective effects of NOS and/or sGC inhibitors combined with antioxidant in LPS-induced organ dysfunction. J FASEB  912:23, 2008.
  21. Schiess MC, Stimming EF, Kaur B, Oh IJ, Poindexter BJ, Kott MM, Bick DML, Doursout MF, Bick RJ:  Cytokine effects on Parkinson associated proteins, alpha synuclein, tau and ubiquitin in cultured glial cells:  localization and density by deconvolution fluorescence microscopy.  Amer Acad Neurol  #P03, 2007
  22. Doursout MF, Hurlburt B, Chelly B, Liang YY, Chelly JE:  Pentoxifylline decreases pro-inflammatory cytokines in prolonged heart failure-induced lung injury.  J. FASEB 21(6): 727, 2007.
  23. Martin E, Sharina I, Doursout MF, Murad F: BMC Pharmacology: Fresh look on old substances – new class of NO-independent regulators of soluble guanylyl cyclase activity and function. 7(S1):55, 2007.
  24. Doursout MF, Liang YY, Chelly B, Welch W, Chelly J: Effects of recombinant platelet factor acetylhydrolase (rPAF-AH) on lung injury in prolonged heart failure.  Journal of Molecular and Cellular Cardiology 42(6):S151-S152, 2007.
  25. Doursout MF, Hurlburt B, Chelly B, Liang YY, Chelly JE:  Pentoxifylline decreases pro-inflammatory cytokines in prolonged heart failure-induced lung injury.  J. FASEB 21: 6: 727.6, 2007.
  26. Doursout MF, Liang YY, Chelly B, and Welch W: Effects of recombinant platelet factor   acetylhydrolase (rPAF-AH) on lung injury in prolonged heart failure.  Journal of Molecular and Cellular Cardiology Supplement 42:1:S151-S152, 2007.
  27. Doursout MF, Sharina IG, Murad F: NO/cGMP Pathway in Diurnal Variations of Cardiac Function in Rats.  J FASEB 4:746:27, 2006.
  28. Doursout MF, Liang YY, Chelly B, Drake RE:  Direct effects of TNF-α fibronectin generation in rats with heart failure.  J FASEB 20:164:15, 2006.
  29. Doursout MF, Liang YY, Chelly B, Chelly JE:  Contribution of the No-sGC pathway in LPS rats.  J FASEB 19(5):A1554, 2005.
  30. Doursout MF, Liang YY, Chelly  B, Sutton A, Graham, Drake R:  Lung expression N-F-қB in prlonged heart failure in rats.  J FASEB 19(5):A1090, 2005.
  31. Doursout MF, Liang YY, Chelly B, Chelly JE:  Contribution of the NO-SGC pathway in LPS rats.  J FASEB 19(5):A1554, 2005.
  32. Doursout MF, Liang YY, Chelly B, Chelly JE:  Contribution of the NO-sGC pathway on cardiac function in rats subjected to moderate hemorrhage.  Anesthesiology A-522, 2005.
  33. Doursout MF, Liang YY, Chelly B, Chelly JE:  Contribution of the NO-sGC pathway on cardiac function in rats subjected to moderate hemorrhage.  Anesthesiology, A-522, 2005.
  34. Doursout MF, Raska E, Chelly B, Liang YY, Bhuiyan MBA, Drake RE:  Lung function in prolonged heart failure in conscious rats.  J FASEB 18(4):A596, 2004.
  35. Doursout MF, Liang YY, Chelly B, Chelly JE:  Nuclear factor – қB activity and arterial response to LPS in rats.  Anesthesiology, 2004.
  36. Doursout MF, Liang YY, Chelly B, Pousman RM, Fischer UM, Bhuiyan BM, Hartley CJ, Chelly JE:  Evaluation of nitric oxide synthase isoforms and tissue specificity in a porcine endotoxin shock model.  J FASEB 17(4):396.1, 2003.
  37. Doursout MF, Liang YY, Chelly JE:  Antinociceptive properties of nitric oxide synthase inhibitors in the rat formalin test.  Can J Anaesth 50:909-916, 2003.
  38. Pousman R, Doursout MF, Fischer U, Liang Y, Chelly B, Chelly JE:  Inhibition of iNOS prevents LPS-induced acute organ injury in conscious pigs. Crit Care Med 30:A53, 2003.
  39. Drake RE, Doursout MF:  Pulmonary edema and elevated left atrial pressure – four hours and beyond.  News Physiol Sci 17:223-226, 2002.
  40. Doursout MF, Liang YY, Chelly JE:  Role of nitric oxide on inflammatory hyperalgesia in rats.  Eur J Anaesthesiol 19:A-746, 2002.
  41. Doursout MF, Joseph PM, Liang YY, Bhuiyan MBA, Hartley CJ, Chelly BO, Chelly JE: iNOS detection in a porcine model of septic shock.  J FASEB 16:443.4, 2002.
  42. Doursout MF, Hartley CJ, Chelly JE:  Comparison of cardiac and regional hemodynamic responses to N-methyl-l-arginine and aminoguanidine infusions in conscious pigs.  J Cardiovasc Pharmacol 37:349-58, 2001.
  43. Doursout MF, Joseph PM, Liang YY, Hartley CJ, Chelly JE:  Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilation in dogs.  Br J Anaesth 89:1-7, 2002.
  44. Doursout MF, Chelly JE:  Protective effects of estrogen in the regulation of nitric oxide pathway during the development of hypertension.  Proc West Pharmacol Soc 45:49-52, 2002.
  45. Doursout MF, Lechevalier T, Liang YY, Chelly F, Hartley CJ, Chelly JE, Kilbourn RG:  Effects of N-methyl-L-arginine on cardiac and regional blood flows in a dog endotoxin shock model.  J Crit Care 15(1):22-29, 2000.
  46. Doursout MF, Wouters P, Kashimoto S, Hartley C, Rabinovitz R, Chelly JE:  Measurement of cardiac function in conscious rats.  Ultrasound Med Biol 27(2):195-202, 2001.
  47. Davidson EM, Doursout MF, Szmuk P, Chelly JE: Antinociceptive properties of esmolol, a following formalin injection in rats.  Can J Anaesth 48(1):59-64, 2001.
  48. Oguchi T, Doursout MF, Kashimoto S, Liang YY, Hartley CJ, Chelly JE: The role of heparin in the cardiac and regional hemodynamic properties of protamine in conscious chronically instrumented dogs.  Anesthesiology 94:1016-1025, 2001.
  49. Nates JL, Doursout MF, Weavind L, Chelly JE:  A thrombelastographic study of lipopolysaccharide induced coagulation abnormalities profile in a pig endotoxemic shock model.  Crit Care Med 27(12):A102, 1999.
  50. Doursout MF, Joseph PM, Chelly JE:  Inducible nitric oxide synthase in various tissues in a porcine endotoxin shock model.  Eur J Anaesthesiol 19:A545, 2000.
  51. Doursout MF, Liang YY, Chelly JE:  Inhibition of nitric oxide synthase by NOS inhibitors:  Cardiovascular and antinociceptive effects.  Exp Biol LB138, 2000.
  52. Doursout MF, Liang YY, Chelly JE:  Role of NOS isoforms on the modulation of pain and associated cardiovascular effects in the rat formalin test.  Anesthesiology 112:A194, 2000.
  53. Doursout MF, Davis KL, Hartley CJ, Chelly JE: Aminoguanidine inhibits sepsis-induced hepatic vasodilation in a porcine model.  J FASEB13(4):146.12, 1999.
  54. Doursout M-F, Nates JL, Weavind LM, Joseph PM, Chelly JE: Role of nitric oxide in coagulation abnormalities in sepsis.  Anesthesiology 91:A282, 1999.
  55. Doursout MF, Liang YY, Davis KL, Hartley CJ, Chelly JE:  Inducible nitric oxide synthase activity in a porcine endotoxin shock model.  Intensive Care Med 24(S1):241, 1998.
  56. Doursout MF, Kilbourn RG, Hartley CJ, Chelly JE: Comparison of responses to aminoguanidine and N-methyl-L-arginine in a porcine endotoxin shock model.  In:  The Biology of Nitric Oxide, Part 6.  Moncada S, Toda N, Maeda H, Higgs EA, (eds.).  London: Portland Press, p. 219, 1998.
  57. Kashimoto S, Doursout MF, Wouters P, Oguchi T, Chelly JE:  Effects of buipivacaine and lidocaine on cardiac function in awake and pentobarbital anesthetized rats.  J Anesth 11:38-43, 1997.
  58. Chelly JE, Doursout MF, Lechevalier T, Liang YY, Chelly F, Hartley C, Kilbourn R: Cardiac and regional hemodynamic interactions between halothane and nitric oxide synthase activity in dogs.  Anesthesiology 85:142-149, 1996.
  59. Lechevalier T, Doursout MF, Chelly JE, Kilbourn R: Cardiovascular effects of N-mono methyl-L-arginine, a nitric oxide synthase inhibitor, in chronically instrumented and conscious dogs.  J Appl  Physiol 77: 471-475. 1994.
  60. Kashimoto S, Doursout MF, Hartley CJ, Chelly JE: Effects of thiopental and ketamine on cardiac function during moderate hemorrhage in chronically instrumented rats.  J Cardiovasc Pharmacol, 21:829-833, 1993.
  61. Doursout MF, Chelly JE, Liang YY, Buckley JP: The ouabain dependent Na+-K+ pump and the brain renin-angiotensin system.  Clin Exp Hyper 14, 1992.
  62. Hysing ES, Chelly JE.  Doursout MF, Merin RG: Cardiovascular effects of acute changes in extracellular ionized calcium concentration induced by citrate and CaCI2 incisions in conscious, chronically instrumented dogs and their interactions with ganglionic blockade. Acta Anaesthesiol Scand 36:16-20, 1992.
  63. Bernard J-M, Doursout MF, Wouters P, Hartley CJ, Merin RG, Chelly JE: Effects of sevoflurane on hepatic circulation in chronically instrumented dogs.  Anesthesiology 77:541-545, 1992.
  64. Hysing ES, Chelly JE, Jacobson L, Doursout MF, Merin RG: Hemodynamic interactions when combining verapamil, acute changes in extracellular ionized calcium concentration and enflurane, halothane or isoflurane in chronically instrumented dogs.  Acta Anaesthesiol Scand 36:806-811, 1992.
  65. Bernard J-M, Doursout MF, Wouters P, Hartley CJ, Cohen M, Merin RG, Chelly JE: Effects of enflurane and isoflurane on hepatic and renal circulation in chronically instrumented dogs.  Anesthesiology 74:298-302, 1991.
  66. Doursout MF, Kashimoto S, Chelly JE:  Cardiac function in the diabetic heart.  In:  The Diabetic Heart.  Nagano M, Dhalla MS (eds.).  New York:  Raven Press, pp 11-19, 1991.
  67. Doursout MF, Chelly JE, Hartley CJ, Johnson D, Lawrence C: Effects of prostaglandins and the autonomic nervous system on the vasodilatory properties of nitroglycerin in conscious dogs.  J Cardiovasc Pharmacol, 16:417-422, 1990.
  68. Doursout MF, Chelly JE, Hartley C, Szilagyi J, Buckley JP:  Regional blood flows and cardiac function changes induced by angiotensin-II in conscious dogs.  J Pharmacol Exp Ther 246:591-596, 1988.
  69. Doursout, MF, Chelly JE: Effects of basal anesthesia on cardiac function.  Br J Anaesth 60:119S-122S, 1988.
  70. Chelly JE, Doursout MF, Begaud B, Tsao CC, Hartley CJ:  Effects of hydralazine on regional blood flow in conscious dogs.  J Pharmacol Exp Ther 238:665-669, 1986.

Workshops

  • Effects of Radiation Exposure on Cardiovascular Health Effects of Acute Radiation-Induced Skin Injury in Rats, NSBRI/TATRC: Institute of Molecular Medicine, UT-Houston, Texas October 2007 and April 2008.

Invited Lectures

  • Institute of Organic Chemistry, Polish Kasprzaba Poland, Warsaw, Poland, Role of sGC isoforms in sepsis-induced organ dysfunction in rodents, June 7-9, 2010.
  • Academy of Medicine Engineering and Science of Texas Annual Conference, Dallas, January 7-9, 2009.

Faculty Biography

Marie-Françoise Doursout, Ph.D.
  • Marie-Françoise Doursout, Ph.D.
    Professor
    Interim Vice-Chairman for Research
  • Department of Anesthesiology
  • The University of Texas Medical School at Houston
    6431 Fannin Street, MSB 3.020
    Houston, Texas 77030
  • phone: (713) 500-0000
    e-mail: Marie-Francoise.Doursout@uth.tmc.edu