Tmb-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation
of a common set of proteins in platelets.
Oda, Atsushi, Brian J. Druker, Hideo Ariyoshi, Marianne Smith, and Edwin W.
Salzman.
Department of Surgery, Beth Israel Hospital, Harvard Medical School,
Boston, Present address: Department of Internal Medicine, School of Medicine,
Keio University, Tokyo, Japan, Present address: Division of Hematology and
Medical Oncology, Oregon Health Sciences University, Portland, Oregon,
Present address: Department of Surgery, Shiten-nouji Hospital, Osaka City,
Japan
APStracts 2:0067C, 1995.
Dibucaine and 8-(N,N-diethylamino) octyl-3,4,5-trimethoxybenxoate (TMB-8),
which are local anesthetics, affect diverse functions of many cell types. For
example, platelet aggregation is inhibited by both, and both cause changes in
platelet morphology and structure. Little is known of the mechanisms.
Received 24 February 1994; accepted in final form 4 January 1995.
APS Manuscript Number C99-4.
Article publication pending Am. J. Physiol. (Cell Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 28 February 1995.