Insulin and the counter-regulatory hormones influence acute phase
protein production in the human hepatocyte.
O'riordain, Michael G., James A. Ross, Kenneth C. H. Fearon, Jean
Maingay, Marwan Farouk, O. James Garden, David C. Carter.
UNIVERSITY DEPARTMENT OF SURGERY, ROYAL INFIRMARY, LAURISTON PLACE,
EDINBURGH EH3 9YW, U.K.
APStracts 2:0052E, 1995.
Following trauma or sepsis, the liver undergoes a re-prioritization of
export protein synthesis with elevated production of some acute phase
reactants, and reduced production of others. We have examined the
effects of combinations of insulin and the counter-regulatory
hormones (dexamethasone, glucagon and epinephrine), in the presence
or absence of IL-6, on the production by isolated hepatocytes of the
positive acute phase proteins C-reactive protein, [alpha]1
-antichymotrypsin, a1-acid glycoprotein and haptoglobin, and the
negative acute phase proteins prealbumin and transferrin. The effect
of IL-6 on the production of the above proteins was influenced
significantly by insulin and all of the counter-regulatory hormones.
Significant three-way interactions, as well as higher order
interactions between the stress hormones and insulin, were seen in
the case of C-reactive protein. The results indicate that both
positive and negative acute phase proteins respond differently to
insulin and the counter-regulatory hormones and that the potential
exists for the regulation of synthesis of individual acute phase
reactants by interaction between the cytokine network and the
classical endocrine hormones.
Received 4 December 1994; accepted in final form 16 March 1995.
APS Manuscript Number E516-4.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 4 April 1995.