Simultaneous treatment with igf-i and gh additively increases
anabolism during total parenteral nutrition in rats.
Lo, Hui-Chen, Pamela S. Hinton, Catherine A. Peterson, and Denise M.
Ney.
Department of Nutritional Sciences, University of Wisconsin
-Madison, Madison, Wisconsin 53706
APStracts 2:0080E, 1995.
We compared the effects of recombinant human insulin-like growth
factor-I (rhIGF-I, 800 [mu]g/day, coinfused with total parenteral
nutrition, TPN), growth hormone (rhGH, 800 [mu]g/day, subcutaneous
injection twice daily), and simultaneous treatment with rhIGF-I and
rhGH (800 + 800 [mu]g/day) in rats subjected to surgical stress and
maintained with TPN. Weight gain induced by IGF-I plus GH was double
that shown by IGF-I or GH alone. Although weight gain was similar
with IGF-I or GH, IGF-I selectively increased heart, kidney, thymus,
spleen, and small intestine mass while GH selectively increased
gastrocnemius muscle mass. IGF-I and/or GH increased carcass protein
and water while decreasing fat. Serum total and free IGF-I levels
were highest with IGF-I plus GH. Serum rat GH levels were reduced
with IGF-I and/or GH. IGF-I given with GH reversed the GH-induced
increase in serum insulin. In summary, IGF-I and GH show tissue
-specific anabolic effects and simultaneous treatment with IGF-I plus
GH additively increases anabolism during TPN.
Received 31 January 1995; accepted in final form 31 March 1995.
APS Manuscript Number E42-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 25 April 1995.