Stimulatory effect of bradykinin on insulin release from the
perfused rat pancreas.
Yang, Chi, and Walter H. Hsu.
Department of Veterinary Physiology and Pharmacology, Iowa State
University, Ames, Iowa 50011
APStracts 2:0018E, 1995.
Rat pancreas perfusion was performed to study the effect of bradykinin
on insulin release. At the perfusate glucose concentration of 6 mM,
bradykinin (0.01 - 1 [mu]M) increased insulin release in a
concentration-dependent manner. In addition, bradykinin (1 [mu]M)
increased the glucose (10 mM)-induced insulin release. HOE140 (0.1
[mu]M), a bradykinin B2-receptor antagonist, decreased the baseline
insulin release and abolished the bradykinin (1 [mu]M)-induced increase
in insulin release. In addition, HOE140 (0.1 [mu]M) attenuated the
glucose (10 mM)-induced increase in insulin release. Because the
blockade of bradykinin receptors by HOE140 attenuated the glucose
-induced increased insulin release, our present findings suggest that
bradykinin may play a physiological role in the regulation of insulin
release.
Received 24 October 1994; accepted in final form 12 January 1995.
APS Manuscript Number E440-4.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 25 February 1995.