Effects of a continuous lipid infusion on glucose metabolism in
critically ill patients.
Tissot, Sylvie, Sylvie Normand, Yadh Khalfallah, Bertrand Delafosse,
Jean Paul Viale, Guy Annat, Jean Motin, Jean Paul Riou.
Service d'Anesth[acute]esie-R[acute]eanimation, H[circumflex]opital
Edouard Herriot, Lyon, France, INSERM U 197, Facult[acute]e de
M[acute]edecine Alexis Carrel, Lyon, France
APStracts 2:0103E, 1995.
The effects of lipid administration on carbohydrate oxidation rate
remain controversial, in particular on critically ill patients. The
aim of this study was to determine the effects in these patients of a
continuous lipid infusion on glucose metabolism using indirect
calorimetry and stable isotopes. We studied 7 patients, mechanically
ventilated, during 2 consecutive 24 hour-periods. Throughout the
first period they received a continuous infusion of glucose (2 mg.kg
-1.min-1) and amino acids. During the second period, in addition to
the above diet, they received a continuous infusion of 1 mg.kg-1.min
-1 of LCT emulsion. Substrate oxidation rates were calculated from
pulmonary gas exchange and nitrogen excretion measurements. Glucose
kinetic parameters were measured using primed constant infusions of
[6,6-2H2]glucose and [1-13C]glucose. The lipid infusion did not
modify the glucose metabolism parameters. 45% of the lipid supply
were stored.
Received 17 January 1995; accepted in final form 2 May 1995.
APS Manuscript Number E13-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 16 May 1995.