Persistence of metabolic consequences in the progeny of rats fed a
hc formula in their early postnatal life.
Vadlamudi, Satyaprasad, Satish C. Kalhan, and Mulchand S. Patel.
Department of Biochemistry, School of Medicine and Biomedical
Sciences, State University of New York at Buffalo, Buffalo, NY 14214
and Department of Pediatrics, Case Western Reserve University School
of Medicine, Cleveland, OH 44106
APStracts 2:0112E, 1995.
First generation (1-) male and female rat pups were either reared
artificially on a high carbohydrate (HC)- or a high fat (HF) formula
or nursed by mother (MF) from day 4 and weaned onto a stock diet on
day 24. 1-HC rats compared to sex-matched controls (1-HF and 1-MF)
were hyperinsulinemic and were mildly obese by day 60. We
investigated the effect of maternal hyperinsulinemia on the second
generation (2-) by intra-group breeding. The 2-HC male and female
rats were hyperinsulinemic on day 45 and had significantly increased
growth rate from day 60 onwards and became obese as evidenced by
increased adipose tissue mass due to hypertrophy on day 100. The
lipogenic capacity of liver and adipose tissues in the 2-HC rats were
significantly higher compared to control rats. Thus, the metabolic
changes which occurred in the 1-rats fed a HC formula during early
postnatal life not only persisted into their adult life but were also
passed onto the next generation.
Received 16 December 1994; accepted in final form 11 May 1995.
APS Manuscript Number E521-4.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 26 May 1995.