Consequences of high dietary fructose in the islet transplanted rat
with suboptimal beta cell mass.
Bell, Rhonda C., Edmond A. Ryan, Diane T. Finegood.
Division of Endocrinology and Metabolism, Dept. of Medicine and the
Dept of Physiology, University of Alberta, Edmonton, Alberta Canada
T6G 2S2
APStracts 2:0196E, 1995.
Fructose feeding in rats provides a model of dietary-induced insulin
resistance which has been used to examine interactions among the
cluster of metabolic disorders including insulin resistance,
hyperinsulinemia, hypertension and dyslipidemia, known as Syndrome X.
In animals with reduced beta cell mass however, insulin resistance
may not have similar associated disorders. Therefore this study
examined the consequences of fructose feeding in rats with a reduced
beta cell mass. Formerly diabetic, islet transplanted (TX) or sham
operated (SHAM) male Wistar Furth were fed a purified control (CNTL)
diet, or a diet containing either 40% or 70% (wt:wt) fructose (FR)
for 3-5 weeks. FR feeding in SHAM animals resulted in elevated
triglyceride levels, but did not affect fed or fasting glucose and
insulin concentrations, blood pressure, glucose tolerance and the
acute insulin response to a glucose bolus compared with CNTL-fed
animals. Among TX animals, hypertriglyceridemia and fasting
hyperglycemia was observed only in those fed FR. Thus the effects of
dietary induced insulin resistance are limited to dyslipidemia if
insulin secretory capacity is adequate, but is detrimental to both
glucose and lipid metabolism when in combination with a reduced beta
cell mass.
Received 8 June 1995; accepted in final form 18 September 1995.
APS Manuscript Number E264-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 November 95