Effects of fish oil on the metabolic responses to oral fructose and
glucose loads in heathy humans.
Delarue, Jacques, Charles Couet, Richard Cohen, Jean-Francois
Br[acute]echot, Jean-Michel Antoine, and Fernand Lamisse.
Laboratoire de Nutrition et Jeune Equipe 313 "Lipides et
Croissance", Universit[acute]e de Tours, 37000-Tours; Service de
Radiopharmacie et de Radioanalyse, H[circumflex]opital Neuro
-Cardiologique, 69003-Lyon; Service de Biochimie, H[circumflex]opital
Trousseau, 37044-Tours. Groupe Danone, Direction Scientifique,
Paris
APStracts 2:0194E, 1995.
This study examines the effect of the substitution of 6 g/d of fish
oil in a saturated diet on glucose and fructose metabolism in healthy
humans. Five subjects were submitted to 2 three-weeks controlled diet
periods (P:S = 0.21). During one period 6 g/d of fat used for
dressing was replaced by 6g/d of fish oil (1.1 g/d of 20:5 w3 and 0.7
g/d of 22:6 w3 fatty acids). At the end of each period the subjects
ingested 2 days apart a 1 g/kg fructose or glucose load. Plasma
glucose fluxes were traced using deuterated glucose and U-13C
-glucose. Substrates oxidation was obtained by indirect calorimetry.
Fish oil induced a 4% increase in basal and post-load glycaemia and a
40% decrease in insulinaemia, whereas plasma C-peptide remained
unaffected. Glucose fluxes were unaffected by fish oil, whereas it
reduced carbohydrate (CHO) oxidation (fructose: 55.5 +/- 4.1 vs 62.9
+/- 3.6 g/6h; glucose: 36.7 +/- 4.7 vs 50.5 +/- 4.7 g/6h; all
p<0.05). Lipid oxidation was 35% increased by fish oil after
both CHO loads. Non oxidative glucose disposal was increased by fish
oil (fructose: 9.4 +/- 2.5 g/6h vs 2.9 +/- 1.1 g/6h; glucose: 28.3
+/- 5.1 vs 14.4 +/- 4.7 g/6h, all p<0.05). Fish oil could affect
glucose transport and decrease CHO oxidation through the decrease in
insulinaemia and/or a specific effect on glycolytic pathway.
Received 20 March 1995; accepted in final form 7 September 1995.
APS Manuscript Number E125-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 31 October 95