Metabolic changes in rats during a continuous infusion of
recombinant il-1.
Ling, Pei Ra, Joseph H. Schwartz, Malayappa Jeevanandam, Jack Gauldie,
Bruce R. Bistrian.
Laboratory of Nutrition/Infection, New England Deaconess Hospital,
Harvard Medical School, Boston, MA; Trauma Metabolism Laboratory, St.
Joseph's Hospital, Phoenix, AZ, and Department of Pathology, McMaster
University, Hamilton, Ontario, Canada
APStracts 2:0188E, 1995.
The effects of recombinant IL-1, given as a continuous infusion for 6
days, on host responses were determined in rats. The development of
fever, change in food intake and body weight, and key components of
the acute phase response in energy and protein metabolism were
assessed. The effects of IL-1 were compared to those observed in a
matched, pair-fed group (semi-starved) to distinquish the
contribution from anorexia, and in a group that received IL-1 for 4
hours acutely. IL-1 significantly increased core temperature, plasma
levels of IL-6 and acute phase protein production, and decreased food
intake and the circulating zinc level. The catabolic effects of IL-1
on nitrogen loss and muscle protein breakdown were independent of,
and additive to those from malnutrition. The changes in energy
expenditure, cumulative urinary nitrogen and hydroxyproline excretion
in the chronic IL-1 group were increased over semi-starved animals.
Finally, changes in muscle protein kinetics were only seen with
chronic IL-1 infusion and the changes in acute phase protein were
greater.
Received 5 June 1995; accepted in final form 24 August 1995.
APS Manuscript Number E258-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.