Adaptation to fat markedly increases the pancreatic secretory
response to intraduodenal fat in the rat.
Spannagel, Alan W., Ikuta Nakano, Tippy Tawil, William Y. Chey, Rodger
A. Liddle, and Gary M. Green.
Department of Physiology, University of Texas Health Science Center
at San Antonio, San Antonio, TX 78284; Center for Digestive and Liver
Diseases, University of Rochester, Rochester, NY 14607; Department of
Medicine, Duke University Medical Center, Durham, NC 27710
APStracts 2:0160G, 1995.
Exposure to higher levels of fat in the diet increases the secretion
of fat-digesting enzymes in pancreatic juice. This study examines the
functional consequences of this phenomenon and demonstrates that
adapting rats to high fat (triglyceride) loads increases the release
of CCK and the pancreatic secretory response to intraduodenal fat.
Lipolytic activity in the small intestine was also higher in adapted
rats. Exchanging pancreatic juice from unadapted rats with pancreatic
juice from adapted rats decreased the response to fat in adapted rats
and increased the response to fat in unadapted rats. Infusing oleic
acid into unadapted rats stimulated CCK secretion and pancreatic
exocrine secretion to levels observed with triglycerides in adapted
rats. Pancreatic exocrine secretion in response to intraduodenal fat
in rats adapted to a high fat (20%) diet were significantly higher
than the responses seen in rats fed a low fat (5%) diet. Adaptation
to fat increases the pancreatic secretory and plasma CCK responses to
fat, apparently by increasing the efficiency of triglyceride
digestion and thereby increasing CCK release.
Received 13 June 1994; accepted in final form 18 July 1995.
APS Manuscript Number G226-4.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 14 August 1995.