Gender influences sphincter of oddi response to cholecystokinin in
the prairie dog.
Tierney, Sean, Zhiping Qian, Babbington Yung, Pamela A. Lipsett, Henry
A. Pitt, Samuel Sostre, Keith D. Lillemoe.
Departments of Surgery and Division of Nuclear Medicine, Johns
Hopkins Medical Institutions, Baltimore, MD 21287
APStracts 2:0085G, 1995.
Although gallstones and disorders of biliary tract motility are both
more common in women than men, sphincter of Oddi motility has not
previously been compared between the sexes. In this study,
cholescintigraphy (under ketamine and diazepam anesthesia) was used
to determine gallbladder emptying rate and ejection fraction in
response to cholecystokinin (CCK) in eight male and six female
prairie dogs fed a non-lithogenic diet. Ten days later, under
[alpha]-chloralose anesthesia, sphincter of Oddi phasic wave activity
was monitored for 10 minute intervals before (control), during 20
minutes of CCK infusion, and for 20 minutes after infusion.
Gallbladder emptying rate and ejection fraction and baseline
sphincter of Oddi frequency, amplitude, and motility index (MI=FxA)
did not differ significantly between the sexes. Sphincter of Oddi
phasic wave frequency was increased during CCK infusion in both males
and females but the change in amplitude was significantly greater in
females than males. We conclude that the increased incidence of
biliary tract disease in women may be due to altered sphincter of
Oddi hormonal response.
Received 19 September 1994; accepted in final form 25 April 1995.
APS Manuscript Number G359-4.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 9 May 1995.