Anaphylactic intestinal response to milk proteins during
malnutrition in guinea-pigs.
Darmon, Nicole, Martine Heyman, C[acute]eline Candalh, Marie
-Agn[grave]es Blaton, and Jehan-Fran[cedilla]cois Desjeux.
Unit[acute]e 290 de l'Institut National de la Sant[acute]e et de la
Recherche M[acute]edicale, H[circumflex]opital Saint-Lazare, 107 rue
du Fg St Denis, 75010 Paris, FRANCE
APStracts 2:0197G, 1995.
We investigated whether sensitization to cow's milk occurs during
malnutrition and alters intestinal ion and macromolecular transport.
Malnourished guinea-pigs received a low protein diet containing
either 4% soya or 4% milk proteins and well nourished sensitized
controls received 26% soya plus 4% milk proteins. To assess milk
sensitization, we measured IgG and passive cutaneous anaphylactic
(PCA) responses to [beta]-lactoglobulin ([beta]-Lg) and the
intestinal anaphylaxis, reflected by the rise in short-circuit
current ([delta]Isc) induced by -Lg in tissues mounted in Ussing
chambers. To assess intestinal function, we measured ionic
conductance and unidirectional fluxes of 14C-mannitol and 3H
-horseradish peroxidase (HRP). In malnourished animals fed milk
proteins, IgG, PCA and [delta]Isc( -Lg) increased more than in well
nourished animals. Ionic conductance and mannitol permeability rose
in both malnourished groups. Malnourished animals fed milk proteins
also displayed enhanced permeability to HRP. These data suggest that
increased paracellular permeability is due to malnutrition per se,
whereas increased macromolecular transport seems to require both
malnutrition and sensitization. They indicate that intestinal
anaphylaxis in response to milk proteins is persistent and even
enhanced during experimental malnutrition.
Received 22 November 1994; accepted in final form 26 September
1995.
APS Manuscript Number G461-4.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 November 95