Frequency of gastric pacesetter potential depends on volume and
site of distention.
Lin, Henry C., Xiao-Tuan Zhao, Benjamin Chung, Yu-Guo Gu, And.
Janet D. Elashoff
APStracts 2:0206G, 1995.
Little is known about the response of the frequency of gastric
pacesetter potential (PP) to luminal distention. When volume
distention occurs as a result of a meal, gastric emptying may play an
important role since the site of distention shifts as the meal is
displaced from the stomach to the small bowel. In this study using
dogs equipped with duodenal fistula and serosal electrodes on the
antrum, we compared the frequency of gastric PP during the course of
gastric emptying while isolating the volume distention to either the
stomach or the small bowel. We found that: 1) the frequency of
gastric PP decreased linearly with greater initial meal volume when
volume distention was isolated to either the stomach (p < 0.05,
ANOVA) or small bowel (P < 0.01, ANOVA); and 2) the frequency of
gastric PP decreased linearly with increased volume remaining in the
stomach or increased volume entering the small intestine. We conclude
that the frequency of gastric PP depends on volume and site of
distention.
Received 4 August 1994; accepted in final form 25 September 1995.
APS Manuscript Number G293-4.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 November 95