Somatostatin receptors.
Reisine, Terry.
Department of Pharmacology, University of Pennsylvania School of
Medicine, Philadelphia, Pennsylvania, 19104. Tele. No. 215-898-1750
and Fax. No. 215-573-2236.
APStracts 2:0181G, 1995.
Somatostatin induces its biological actions by activating a family of
receptor subtypes. The recent cloning of five somatostatin receptor
subtypes has lead to the development of subtype selective agonists.
These compounds are revealing distinct functions of the individual
receptor subtypes. Mutagenesis studies have revealed domains of
several of the receptors involved in specific recognition of
somatostatin analogs. Molecular modeling of both these ligand binding
domains and the constrained somatostatin analogs that they interact
with may lead to the development of non-peptide somatostatin drugs
which could be useful in the treatment of tumors and various
metabolic, gastrointestinal and central nervous system disorders.
Received 29 March 1995; accepted in final form 18 August 1995.
APS Manuscript Number G379-5.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.