Cardiac myocytes release leukocyte stimulating factors.
Massey, Kenneth D., Robert M. Strieter, Steven L. Kunkel, Jean M.
Danforth, and Theodore J. Standiford.
Department of Anesthesiology, Department of Pathology, and the
Department of Medicine, Division of Pulmonary and Critical Care, The
University of Medicine Medical School, Ann Arbor, Michigan 48109
APStracts 2:0125H, 1995.
The production of cytokines directly from cardiac myocytes has not
been previously demonstrated and could represent an important
mechanism and site of intervention in ischemia and reperfusion
injuries. Macrophage inflammatory protein-2 (MIP-2) and monocyte
chemotactic protein (MCP) are chemokines which stimulate PMNs and
monocytes, respectively. Endothelium has been implicated as being a
major cellular source of leukocyte activating factors. We
hypothesized that the myocardial cells may also play an important
role in producing chemotactic cytokines (chemokines), independent of
endothelium.
Received 28 October 1994; accepted in final form 7 March 1995.
APS Manuscript Number H959-4.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 10 April 1995.