Seven days of exercise increases glut-4 protein content in human
skeletal muscle.
Houmard, Joseph A., Matthew S. Hickey, Gilian L. Tyndall, Karen E.
Gavigan, and G. Lynis Dohm.
Human Performance Laboratory and Department of Biochemistry, East
Carolina University, Greenville, NC 27858 USA
APStracts 2:0326H, 1995.
Insulin-responsive glucose transporter (GLUT-4) content increases by
1.8-fold in skeletal muscle with 14 weeks of exercise training
(Houmard et al., Am. J. Physiol. 264:E896-E901, 1993). The purpose of
this study was to determine if more short-term training (7 days)
increases GLUT-4 protein content in human skeletal muscle. Seven
sedentary men (mean + SE; age, 25.0 + 1.1 years; VO2max, 44.1 + 2.2
ml/kg/min; body fat percentage, 14.9 + 2.1%) were examined before and
after 7 days of cycle ergometer training (1 hour/day, 76 + 2% maximal
heart rate). Needle biopsy samples from the vastus lateralis were
used to determine GLUT-4 protein content. Muscle GLUT-4 increased
(P<0.05) by an average of 2.8 + 0.5 fold with 7 days of
training. GLUT-4 content in skeletal muscle thus increases
substantially with short-term exercise training.
Received 1 May 1995; accepted in final form 24 July 1995.
APS Manuscript Number H63-5.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 10 August 1995.