Cerebral o2 transport with hematocrit reduced by crosslinked
hemoglobin transfusion.
Ulatowski, John A., Enrico Bucci, Toshiaki Nishikawa, Anna Razynska,
Michael A. Williams, Reiko Takeshima, Richard J. Traystman, and
Raymond C. Koehler.
Department of Anesthesiology/Critical Care Medicine, The Johns
Hopkins Medical Institutions, Baltimore, Maryland 21287 and
Department of Biological Chemistry, School of Medicine, University of
Maryland at Baltimore, Baltimore, Maryland 21201
APStracts 2:0331H, 1995.
The purpose of this study was to dissociate effects of reduced
viscosity from those of low arterial O2 content (CaO2) on cerebral
blood flow (CBF) during anemia. Three groups (n=8) of pentobarbital
-anesthetized cats were studied: 1) a time control group with a
hematocrit of 32 +/- 1% (SE); 2) an anemia group which underwent an
isovolemic exchange transfusion with albumin in a salt solution to
decrease hematocrit to 18 +/- 1%; and 3) a group transfused with
cell-free, tetramerically-stabilized hemoglobin to decrease
hematocrit equivalently to that in the albumin transfused group. CaO2
in the hemoglobin transfused group (11.8 +/- 0.3 ml/dl) and control
group (15.0 +/- 0.6 ml/dl) were greater than that in the albumin
group (8.7 +/- 0.3 ml/dl). CBF in the hemoglobin group (45 +/- 3 ml x
min-1 x 100g-1) and control group (36 +/- 4 ml x min-1
Received 2 December 1994; accepted in final form 21 July 1995.
APS Manuscript Number H1055-4.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 14 August 1995.