APStracts 2:0197H, 1995.

Ischemia/reperfusion-induced alteration of blood-brain barrier transport in newborn pigs. Temesv[acute]ari, P., F. Jo[acute]o, J. Kov[acute]acs, C. S. Brah[acute]am. Department of Pediatrics, Albert Szent-Gy[diaeresis]orgyi Medical University, P.O. Box 471, H-6701 Szeged, and Laboratory of Molecular Neurobiology, Biological Research Center, P.O. Box 521, H-6701 Szeged; Hungary

APStracts 2:0197H, 1995.

We have read with interest the paper from S.L. Zuckerman et al. (9), who published their observations regarding to cerebral ischemia -reperfusion evoked enhanced sodium and albumin transport through the blood-brain barrier (BBB) in newborn piglets. After a 20-min-ischemia sodium (22Na) and radioiodinated albumin transfer were determined at 2 h reperfusion in different brain regions. They demonstrated that both tracers passed BBB which could be prevented by indomethacin pretreatment. Endothelial vesicular transport enhancement and increased cyclic nucleotide activity were hypothesized as causative factors in the alterations in BBB permeability in early postischemic reperfusion.

Received 28 March 1995; accepted in final form 8 May 1995.
APS Manuscript Number H301-5.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 26 May 1995.