APStracts 2:0479H, 1995.

A novel guinea-pig heart model for studying atrio-ventricular nodal conduction and triggered activity in vivo. Jiang, Xu Amir Pelleg. Likoff Cardiovascular Institute, Medical College of Pennsylvania and Hahnemann University, Philadelphia, PA

APStracts 2:0479H, 1995.

A novel model is described which enables for the first time the recording of the His bundle activity (HBE), monophasic action potential (MAP) and early (EADs) and delayed (DADs) afterdepolarizations in the guinea-pig heart in vivo. In this model, custom-made catheter electrodes have been used; their detailed design, a recipe for their construction and the modes of their operation are given in details. In addition, examples of experimental data obtained using this model are given. These include values of AH and HV intervals as well as DADs associated with digoxin-induced ventricular arrhythmias. The present is a small and relatively inexpensive model in which studies of atrio-ventricular (AV) nodal conduction as well as afterdepolarizations/triggered activity can be performed in vivo.

Received 22 March 1995; accepted in final form 6 October 1995.
APS Manuscript Number H275-5.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 November 95