Early changes in protein synthesis in epicardial coronary artery of
pressure-overloaded heart.
Gerov[acute]a, M[acute]aria, Oga Pech[acute]a[grave]oov[acute]a,
Venceslav Stoev, Margita Kittov[acute]a Iveta
Bern[acute]atov[acute]a, Ervin B[acute]arta.
Institute of Normal and Pathological Physiology, Slovak Academy of
Sciences, and Institute of Physiology, Medical Faculty Comenius
University, Bratislava, Slovak Republic
APStracts 2:0383H, 1995.
In anaesthetised dogs a 4 hour lasting increase in blood pressure by
about 30%, induced by constriction of the abdominal aorta, brought
about an increase in the total RNA content in the left anterior
descending coronary artery (LADCA) and in the left ventricular
myocardium (9.05 +/- 1.72% and 11.06 +/- 4.68% respectively), but not
in the left circumflex coronary artery (LCCA). Under the same
experimental conditions, [14C]leucine incorporation increased in
LADCA and left ventricular myocardium (45.34 +/- 13.54%, 58.07 +/-
11.91% respectively), however, not in LCCA. The data indicate an
early shift in protein synthesis in LADCA, and simultaneously in the
myocardium during a short term pressor event. The difference in the
shift of protein synthesis in the two main branches of the left
coronary artery was related to the quantitatively different
deformation of the LADCA and LCCA due to different deformation of the
underlying myocardium and/or of the annulus fibrosus
atrioventricularis during changes in the left or right ventricle
volume (Gerov[acute]a et al Am. J. Physiol. 1992). The results
support thehypothesis that the deformation and/or the rate of
deformation of the cells in the coronary wall may by the trigger
factor of an increase in protein synthesis. The changes in protein
synthesis in the myocardium and LADCA were found to be reversible two
hours after setting free the aortic constriction.
Received 10 November 1993; accepted in final form 31 July 1995.
APS Manuscript Number H1002-3.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.