Endurance run increases circulating il-6 and il-1ra but down
-regulates ex-vivo tnf[alpha] and il-1[beta] production.
Drenth, Joost P. H., Stan H. M. Van Uum, Marcel Van Deuren, Gerard J.
Pesman, Johanna Van Der Ven-Jongekrijg, Jos W. M. Van Der Meer.
Department of Medicine, Division of General Internal Medicine, and
Laboratory of Endocrinology and Reproduction, University Hospital St.
Radboud, Nijmegen, The Netherlands
APStracts 2:0343A, 1995.
We investigated whether a 6-hour endurance run changes cytokine plasma
concentrations and LPS stimulated ex-vivo production of cytokines in
a whole blood culture of 19 well trained athletes. The average
distance covered was 65.1 (SD 8.64 km). At the end of the exercise,
the mean plasma concentration of IL-1ra, which was 188 pg/ml 24 hours
before finish, increased to 886 pg/ml. (p < 0.0005) The mean
plasma IL-6 concentration increased from 18.5 +/- 4.2 to 71.5 +/-
33.3 pg/ml. (p < 0.0001) The increase of neutrophils correlated
with the increase of IL-1ra concentrations, (r = 0.58, p <
0.005). We could not detect an effect of exercise on plasma
concentrations of IL-1[beta] or TNF[alpha]. The ex-vivo LPS
stimulated production of IL-1[beta] in athletes 24 hours before the
run was significantly higher than in sedentary controls. Exercise
induced a decrease of LPS stimulated production of IL-1[beta] and
TNF[alpha] whereas production of IL-1ra was unchanged. These results
show that prolonged exercise elicits a selective downregulation of
the proinflammatory cytokine production and upregulation of the
cytokines IL-1ra and IL-6.
Received 24 March 1995; accepted in final form 14 June 1995.
APS Manuscript Number A327-5.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 10 August 1995.