Pulmonary responses to heparin-protamine complexes: the effects of
age and species.
Horiguchi, Takashi, Keiji Enzan, Koichi Kawamura, and Masahiro Suzuki.
Department of Anesthesia, Akita Kumiai Hospital, Akita 011, Japan;
Department of Emergency Medicine, Akita University Medical Center,
Akita 010, Japan; Second department of Pathology and Department of
Anesthesiology, Akita University School of Medicine, Akita 010,
Japan
APStracts 2:0372A, 1995.
To test the hypothesis that heparin-protamine complexes (H-P
complexes) react with pulmonary intravascular macrophages (PIMs), we
studied the difference in the pulmonary reaction to H-P complexes
between goats and rabbits, and among different aged goats. The
increases in pulmonary arterial pressure (Ppa) and plasma thromboxane
levels (Tx) after injection of H-P complexes (1.2 ml/kg) in goats
(_Ppa=17 +/- 7.0 mmHg, _Tx=17.3 +/- 10.1ng/ml) were significantly
greater than in rabbits (_Ppa=0.50 +/- 1.0 mmHg, _Tx= - 0.01+/- 0.17
ng/ml), the increase in Ppa in adult goats (over 150 days old,
_Ppa=17 +/- 7.0 mmHg) was about 6 fold higher than in newborn goats
(1-3 days old, _Ppa=2.8 +/- 4.0 mmHg), and the increase in Tx
(_Tx=17.3 +/- 10.1 ng/ml) was significantly greater than that in
newborn and young (19 days old) goats (_Tx=0.69 +/- 0.48, and 3.60
+/- 0.36 ng/ml, respectively). The pulmonary hemodynamic reaction to
H-P complexes is consistent with the concept that the H-P complexes
react with PIMs.
Received 19 May 1994; accepted in final form 18 August 1995.
APS Manuscript Number A513-4.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 24 August 1995.