Multifrequency bioelectrical impedance estimates the distribution
of body water.
Cha, Kichul, Glenn M. Chertow, Jorge Gonzalez, J. Michael Lazarus, and
Douglas W. Wilmore.
Laboratories for Surgical Metabolism and Nutrition, Department of
Surgery, and Renal Division, Department of Medicine, Brigham and
Women's Hospital and Harvard Medical School, Boston, MA
APStracts 2:0247A, 1995.
Multifrequency bioelectrical impedance analysis (MFBIA) was used to
estimate the ratio of extracellular water (ECW) to total body water
(TBW) in subjects with end-stage renal disease (ESRD). The body's
resistance was measured at frequencies ranging from 1 KHz to 1 MHz.
The impedance index (Height2/Resistance or Ht2/R) determined at low
frequency (5 KHz) correlated most closely with ECW (r=0.886) using
sodium bromide dilution as the standard of comparison. In contrast,
Ht2/R determined at high frequency (500 KHz) correlated most closely
with TBW (r=0.974) using deuterium oxide dilution as the standard of
comparison. The ratio of R500KHz/R5KHz was directly correlated
(r=0.767) with the ECW/TBW ratio. MFBIA may assist in the evaluation
of body water distribution in ESRD and other clinical disorders of
fluid volume and/or distribution. (138 words)
Received 31 March 1995; accepted in final form 26 May 1995.
APS Manuscript Number A360-5.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 July 1995.