Effects of a perfluorocarbon emulsion for enhanced oxygen
solubility on hemodynamics and oxygen transport in dogs.
Johnson, Emily C., B. Kipp Erickson, Andrea Podolsky, Eric K. Birks,
Peter E. Keipert, N. Simon Faithfull, and Peter D. Wagner.
Department of Medicine, University of California, San Diego, La
Jolla, CA 92093-0623 USA, 2Alliance Pharmaceutical Corp., San Diego,
CA 92121 USA
APStracts 2:0264A, 1995.
Perfluorocarbon emulsions raise blood O2 solubility and thus augment
O2 transport, but their cardiopulmonary effects at higher doses may
limit their use. We therefore examined effects of increasing doses of
perfluorooctylbromide (OXY) on 1) pulmonary gas exchange; 2)
pulmonary and systemic hemodynamics; and 3) mixed venous Po2 (P_vo2).
After hematocrit (Hct) reduction to 24-26% by exchange with 5%
albumin, anesthetized, ventilated dogs breathing 100% O2 were given
OXY (n=6) or 5% albumin (CON; n=5) i.v. in four successive 3 ml/kg
doses. After each dose, arterial and venous Po2, Pco2, pH, [O2], Hct,
heart rate, and systemic, pulmonary arterial, and airway pressures
were measured. a/ relationships and cardiac output (t) were
determined by the multiple inert gas method. Twelve ml/kg of OXY
almost doubled blood O2 solubility, increasing arterial [O2] by 1.28
ml/100ml while o2 and a/ relationships were unaffected. t rose by 21%
after 3 ml/kg, then fell with increasing doses (-18% from baseline
after 12 ml/kg); O2 delivery remained constant. OXY >6 ml/kg
increased systemic blood pressure systemic vascular resistance (SVR)
considerably. Mean pulmonary artery pressure and pulmonary vascular
resistance increased slightly. Airway pressures were unaffected.
P_vo2 rose from 66 to 77 Torr (6 ml/kg), then fell to 72 Torr (12
ml/kg), in accord with theoretical predictions. In this model, OXY:
1) does not impair pulmonary gas exchange in doses up to 12 ml/kg; 2)
leads to progressively higher SVR, and fall in t at doses >3-6
ml/kg, possibly due to increased blood viscosity; and 3) augments
P_vo2 as predicted from the increase in plasma O2 solubility.
Received 7 February 1994; accepted in final form 7 June 1995.
APS Manuscript Number A141-4.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 July 1995.