Apolipoproteins after exercise in men with high cholesterol: influence of intensity. Crouse, Stephen F., Barbara C. O'brien, J. James Rohack, Robert C. Lowe, John S. Green, Homer Tolson, Judy L. Reed,. FACSM, Applied Exercise Science Laboratory, Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843, Department of Biochemistry/Biophysics, Texas A&M University, College Station, Texas 77843, College of Medicine, Health Science Center, Texas A&M University, College Station, Texas 77843, Department of Kinesiology and P.E., University of Central Arkansas, Conway, Arkansas 72032, FACSM, Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843, Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843, Department of Health and Physical Education, Sam Houston State University, Huntsville, Texas 77340
APStracts 2:0094A, 1995.
Blood lipid concentrations may change immediately and up to 72 hours after exercise in normocholesterolemic men; these changes may be affected by the intensity at which the exercise is performed. However, the effects of a single session of exercise at different intensities on blood lipid profiles in hypercholesterolemic men have not been studied. The purpose of this study was to characterize the short-term changes in blood lipid and apolipoprotein concentrations after high (80% O2max; n=20) or moderate (50% O2max; n=19) intensity cycle ergometer exercise in healthy, hypercholesterolemic men (mean +/- SEM cholesterol = 254 +/- 6 mg x dL-1); the exercise sessions were balanced for caloric expenditure (350 kcal). The men's age, height, weight, %fat, and O2max were (+/- SEM) 46 +/- 2 yr, 173 +/- 7 cm, 82.7 +/- 2.2 kg, 28 +/- 1%, and 31.1 +/- 1.0 mlO2 x kg-1 x min-1, respectively. Blood samples were drawn before exercise, immediately after, then 24 and 48 h later, and concentrations of all variables were adjusted for changes in plasma volume. Significant changes (p < 0.0016) were as follows: total- and LDL-cholesterol fell 4% immediately after exercise, then rose 5-8% by 48 h. Triglycerides were 18% and 15% lower at 24 and 48 h. HDL-cholesterol, HDL3 -cholesterol, and apoprotein B rose 8-9% by 24 h and remained elevated. HDL2-cholesterol rose 27% by 48 h after exercise, but this change was not significant. Apoprotein A-I did not change with exercise. The response patterns were not affected by exercise intensity. These data show that a single session of exercise performed by untrained, hypercholesterolemic men alters blood lipid and apolipoprotein concentrations. Furthermore, the post-exercise response patterns are not influenced by the intensity at which the exercise is performed, as long as caloric expenditure is held constant. 

Received 19 September 1994; accepted in final form 2 March 1995.
APS Manuscript Number A975-4.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 21 March 1995.