The effect of marathon run on serum insulin-like growth factor (
igf)-i and igf-binding proteins 1 and 3 levels.
Koistinen, Hannu, Riitta Koistinen, Linnea Selenius, Olavi Ylikorkala,
Markku Sepp[umlaut]al[umlaut]a.
Department of Obstetrics and Gynecology, Helsinki University
Central Hospital, Finland
APStracts 2:0457A, 1995.
Acute physical exercise increases growth hormone (GH) secretion, and
GH regulates expression of insulin-like growth factor-I (IGF-I) and
IGF-binding protein-3 (IGFBP-3). IGFBP-1 is a local modulator of IGF
activity with rapid dynamic regulation, downregulated by insulin. The
IGF-system mediates the metabolic actions of GH and possibly in
regulates glucose metabolism. We hypothesize that strenuous exercise
causes changes in IGF-system. We studied the effects of the marathon
run on the circulating levels IGF-I, IGFBP-1, IGFBP-3 and insulin in
23 participants.
Received 6 July 1995; accepted in final form 12 October 1995.
APS Manuscript Number A719-5.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 November 95