Mechanisms of postischemic injury in skeletal muscle: intervention
strategies.
Rubin, Barry B., Alexander Romaschin, Paul M. Walker, Dean C. Gute,
and Ronald J. Korthuis.
R. Fraser Elliott Vascular Research Laboratory, The Toronto
Hospital, University of Toronto, Department of Surgery, Toronto,
Ontario, Canada and Department of Physiology, Louisiana State
University Medical Center, School of Medicine in Shreveport,
Shreveport, LA
APStracts 2:0490A, 1995.
Reperfusion of ischemic skeletal muscle leads to adverse local and
systemic effects. These detrimental effects may be attenuated by
interfering with or modulating the pathophysiologic processes which
are set in motion during ischemia and/or reperfusion. The purpose of
this paper is to review the different intervention strategies which
have been employed in an attempt to elucidate the mechanisms involved
in the pathogenesis of skeletal muscle ischemia/reperfusion injury.
The results of these studies indicate that the postischemic injury
processes that lead to cell dysfunction and death are multifactorial
in nature and include oxidant generation, elaboration of
proinflammatory mediators, infiltration of leukocytes, Ca++ overload,
intravascular coagulation and reduced ATP production. Although the
etiopathogenesis of skeletal muscle ischemia/reperfusion is complex,
careful delineation of the mechanisms which contribute to
postischemic microvascular dysfunction and muscle necrosis has
progressed to the point where rational intervention strategies may be
proposed and implemented as potential treatments for skeletal muscle
dysfunction associated with ischemia/reperfusion.
Received 16 May 1995; accepted in final form 27 September 1995.
APS Manuscript Number A512-5.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 30 November 95