Flow-Mediated Endothelial Mechanotransduction.
Davies, Peter F.
Department of Pathology, Pritzker School of Medicine, The University of
Chicago, Chicago, Illinois.
APStracts 2:0002P, 1995.
ABSTRACT
Mechanical forces associated with blood flow play important roles in the acute
control of vascular tone, the regulation of arterial structure and remodeling,
and the localization of atherosclerotic lesions. Major regulation of the
blood vessel responses occurs by the action of hemodynamic shear stresses on
the endothelium. The transmission of hemodynamic forces throughout the
endothelium and the mechanotransduction mechanisms that lead to biophysical,
biochemical, and gene regulatory responses of endothelial cells to
hemodynamic shear stresses are reviewed.
APS Manuscript Number P-0003-5.
Article publication scheduled July 1995 Physiological Reviews.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 16 May 1995.