Dynamics of Nerve-Muscle Interaction in Developing and Mature Neuromuscular
Junctions.
Grinnell, Alan D.
Dept. of Physiology, The Jerry Lewis Neuromuscular Research Center and the
Ahmanson Laboratory of Neurobiology, University of California, Los Angeles,
School of Medicine, Los Angeles, California.
APStracts 2:0013P, 1995.
ABSTRACT
Neuromuscular connections have long served as models of synaptic structure and
function. They also provide illuminating insights into the dynamic cell-cell
interactions governing synaptogenesis, neuromuscular differentiation, and the
maintenance of effective function. This paper reviews recent advances in our
understanding of the regulatory and inductive interactions involved in motor
axon pathfinding, target recognition, bidirectional control of gene expression
during synapse formation, motoneuron cell death, terminal rearrangement, and
the ongoing remodeling of synaptic number, structure, and function to adjust
to growth and changes in use.
APS Manuscript Number P-0015-5.
Article publication scheduled October 1995 Physiological Reviews.
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.