The time course for the entry of intestinally infused lipids into
the blood of rats.
Greenberg, Danielle, Ruth A. Kava, Dacie R. Lewis, M. R. C. Greenwood,
and Gerard P. Smith.
Department of Psychiatry, Cornell University Medical College, and
the Edward W. Bourne Behavioral Research Laboratory, The New York
Hospital - Cornell Medical Center, Westchester Division White Plains,
New York 10605; Department of Biology, Vassar College, Poughkeepsie,
New York 12601; and Department of Nutritional Sciences, University of
California at Davis, Davis, California 95616
APStracts 2:0071R, 1995.
The early time course of the absorption of duodenally infused [14]C
-labeled Intralipid into either the hepatic portal circulation or the
systemic circulation was measured. Plasma radioactivity did not
increase significantly at either site until 30 min after the
intestinal infusion began and was maximal between 60 and 120 min. In
studies on the effects of intestinal lipid infusions on sham feeding
in rats we find significant suppressions of sham feeding after only
10 min. Thus, the time course for lipid absorption is different than
that of the satiating effects of duodenally infused fats. These
results are consistent with the hypothesis that the satiating effect
of fats infused into the small intestine occurs prior to the entry of
absorbed fats into the blood and is not dependent on recently
absorbed circulating fat.
Received 6 October 1994; accepted in final form 14 March 1995.
APS Manuscript Number R582-4.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 6 April 1995.