A comparison of the effects of adrenalectomy and mifepristone (ru
486) in rats given a choice of maintenance diet and fat
supplement.
Trocki, Orrawin, David J. Baer, Thomas W. Castonguay.
Dept of Nutrition and Food Science, University of Maryland, College
Park, MD 20742 and USDA, ARS, Energy and Protein Nutrition
Laboratory, Beltsville Human Nutrition Research Center, Beltsville,
MD 20705
APStracts 2:0095R, 1995.
The effects of adrenalectomy (ADX) and the blockade of glucocorticoid
receptors by RU 486 on Sprague-Dawley rats given a choice of a
maintenance diet and a fat supplement was studied. Adult male rats
were given either free access to AIN-76A diet only (CON) or AIN-76A
diet and a separate dietary fat option for 4 wk (FAT). They were then
assigned to one of the following treatments: ADX; sham operation; ADX
with corticosterone (CORT) replacement; RU 486 injections; or vehicle
injections. Food intake and body weight were monitored daily for an
additional 3 wk. ADX decreased caloric intake and weight gain in the
FAT group more than in the CON group. RU 486 also decreased caloric
and fat option intakes as well as weight gain. ADX, but not RU 486,
reduced body fat content, lowered plasma insulin and triglyceride
levels, and decreased glucose intolerance. CORT replacement partially
prevented the effects of ADX on weight gain and body fat content. The
results of this study indicate that ADX has greater effects on weight
gain and body fat accumulation than does RU 486.
Received 13 December 1993; accepted in final form 30 March 1995.
APS Manuscript Number R673-3.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 10 April 1995.