Hypothalamic neuronal histamine modulates physiological responses
induced by interleukin-1[beta].
Kang, Masahiro, Hironobu Yoshimatsu, Seiichi Chiba, Mamoru Kurokawa,
Ryuichi Ogawa, Yuichi Tamari, Mari Tatsukawa, and Toshiie Sakata.
Department of Internal Medicine I, School of Medicine, Oita Medical
University, Oita, 879-55 Japan
APStracts 2:0232R, 1995.
Dynamic involvement of hypothalamic histamine in ingestive behavior
and thermogenesis induced by interleukin-1[beta] (IL-1[beta]) was
examined in rats. Intraperitoneal injection of 0.12 nmol/rat IL
-1[beta] decreased food and water intake, and elevated body
temperature. However, depletion of neuronal histamine induced by
intraperitoneal injection of 160 [mu]mol/rat [alpha]
-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase
(HDC), attenuated the suppressive effect of IL-1[beta] on food
intake, facilitated the suppressive effect on drinking, and enhanced
the elevating effect on rectal temperature. Intraperitoneal injection
of 0.12 nmol/rat IL-1[beta] increased hypothalamic histamine turnover
rate. The same dose of IL-1[beta] also increased activity of HDC and
histamine-N-methyltransferase (HMT). These results suggest that IL
-1[beta] may stimulate synthesis and release of hypothalamic histamine
in presynaptic terminals by activation of HDC, and facilitate
degradation of extracellular histamine by activation of HMT. These
changes in the dynamics of hypothalamic histamine modulate IL
-1[beta]-induced ingestive behavior and body temperature.
Received 22 December 1993; accepted in final form 13 June 1995.
APS Manuscript Number R694-3.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 24 August 1995.