Interaction of type i and type ii corticosteroid receptor
stimulation on carcass energy and carcass water.
White, B. Douglas, Gaylen L. Edwards, and Roy J. Martin.
Departments of Foods and Nutrition, and Physiology and
Pharmacology, University of Georgia, Athens, Georgia 30602
APStracts 2:0344R, 1995.
The effects of chronic Type I and Type II corticosteroid receptor
stimulation were examined in adrenalectomized Sprague-Dawley rats to
quantify the relative contribution of body energy and body water
changes to changes in body weight. Adrenalectomy caused a decrease in
both body energy and water. Aldosterone (Type I agonist) treatment
increased body weight gain and returned energy accretion to the level
of sham animals. However, most of the change in body weight (72%) was
attributable to a change in body water. The aldosterone-induced
increase in body weight gain and carcass water were attenuated by
RU28362 (Type II receptor agonist) infusion, suggesting that Type II
receptor stimulation can antagonize the effect of Type I receptor
stimulation. Changes in carcass water were paralleled by changes in
soluble carcass sodium. Despite alterations soluble body sodium, no
measurable differences in cumulative sodium retention were found.
These findings confirm previous studies suggesting an effect of Type
I receptor stimulation on energy accretion. However, they also
caution that changes in body weight can not be equated with changes
in body energy.
Received 17 October 1994; accepted in final form 7 December 1995.
APS Manuscript Number R601-4.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 December 95