Intestinal fat differentially suppresses sham feeding of different
gustatory stimuli.
Foster, L. A., K. Nakamura, D. Greenberg, and R. Norgren.
Department of Behavioral Science, College of Medicine, The
Pennsylvania State University, Hershey, PA 17033; and Department of
Psychiatry, New York Hospital-Cornell Medical Center, White Plains,
New York 10605
APStracts 2:0350R, 1995.
In order to determine the intestinal contribution to short term
satiety for solutions of varying palatability, 0.15 M NaCl or lipid
(Intralipid, 10 ml, 0.125, 0.25, 0.5, 1.0 kcal/ml) was infused at a
rate of 0.5 ml/min into the duodenum of rats that were sham feeding
either a liquid diet (0.5 Kcal/ml), 0.3 M sucrose (0.4 Kcal/ml), or a
0.1 M solution of glucose polymers (Polycose 0.4 Kcal/ml).
Differences in palatability were estimated by the total consumption
of each solution over 90 min in a one bottle test. The intake of
solutions maximally ingested during the saline infusions (Polycose
> Sucrose > liquid diet) were the most sensitive to the
lipid infusions. All four lipid concentrations suppressed intake of
Polycose, the solution consumed the most, the three highest
concentrations suppressed intake of sucrose (intermediate
consumption), and only the two highest concentrations suppressed
intake of the complete diet, the solution consumed the least.
Nevertheless, the duration of suppression was shorter for the
solutions the rats drank the most. For the solution the rats drank
the least (liquid diet), the two high concentrations of lipid that
suppressed intake, did so for the entire experimental period. Whereas
for Polycose, all lipid infusions suppressed intake, but it recovered
to control levels for all but the highest concentration. Other
studies have reported that increasing diet palatability shortens the
duration of satiety. The current results suggest that this effect may
reflect the duration of intake suppression elicited by nutrients in
the intestine.
Received 19 January 1995; accepted in final form 30 November
1995.
APS Manuscript Number R45-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 December 95