APStracts 2:0026R, 1995.

Choroid plexus electrolytes and ultrastructure following transient forebrain ischemia. Palm, Donald, Neville Knuckey, Maria Guglielmo, Peter Watson, Michael Primiano, and Conrad Johanson. Program in Neurosurgery, Department of Clinical Neurosciences, Brown University/Rhode Island Hospital, Providence, RI 02903

APStracts 2:0026R, 1995.

A temporal profile of lateral and fourth ventricle rat choroid plexus (LVCP and 4VCP, respectively) tissue injury and recovery was determined using alterations in K, Na and H2O content and ultrastructure following 10 min of transient forebrain ischemia (TFI). At 0.5 hr post-ischemia the LVCP displayed a maximum reduction in K content by 32% and a significant increase in Na content by 85% and H2O content by 22%. LVCP tissue K, Na and H2O content returned to sham values by 24 hr post-ischemia. Ultrastructural changes appeared more severe between 0.5 and 12 hr post-ischemia, whereas by 24 hr, normal ultrastructure was restored. Elevations in 4VCP tissue Na (p<0.05) and H2O content, which were less than those in LVCP, gradually reached a maximum by 24 hr compared to sham. No change in 4VCP tissue ultrastructure was observed. These results indicate that the LVCP tissue is more vulnerable than 4VCP in the bilateral carotid artery occlusion model, but that it recovers in a timely manner following TFI. Furthermore, the ability of the LVCP tissue to rapidly recover suggests its functional importance in helping to restore brain homeostasis.

Received 2 August 1994; accepted in final form 22 January 1995.
APS Manuscript Number R422-4.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 25 February 1995.