Intraluminal lipids modulate avian gastrointestinal motility.
Mart[acute]inez, V., M. Jim[acute]enez, E. Go[tilde]nalons, and P.
Vergara.
Department of Cell Biology and Physiology, Veterinary Faculty,
Universitat Aut[grave]onoma de Barcelona, 08193 Bellaterra,
Spain.
APStracts 2:0051R, 1995.
The infusion of lipids into the ileum delays gastric emptying and
intestinal transit time in some species. The aim of this study was to
characterize the actions of intraluminal lipid infusion on
gastrointestinal electrical activity in chickens. Animals were
prepared for electromyography with chronic electrodes in stomach,
duodenum and small intestine. Two catheters were chronically placed
in the esophagus and ileum to infuse equimolar doses of either oleic
acid (OA) or triolein (TO). Both OA and TO, esophageally infused,
inhibited the frequency of the gastroduodenal cycle and increased the
frequency of antiperistaltic spike bursts in the duodenum. Ileal
infusion of OA, but not of TO, produced the same effects. Both
esophageal and ileal OA infusion increased the duration of the
migrating myoelectric complex (MMC) and decreased the speed of
propagation of the phase III. In conclusion, intraluminal infusion of
lipids modulates gastrointestinal motility decreasing the frequency
of the gastric cycle, increasing duodeno-gastric refluxes and
elongating the MMC. These actions could delay gastric emptying and
increase transit time, which suggests the presence of an "ileal
brake" mechanism similar to that described in mammals.
Received 13 May 1994; accepted in final form 18 February 1995.
APS Manuscript Number R253-3.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 1 March 1995.