Does ingested fat produce satiety?.
Horn, Charles C., Michael G. Tordoff, and Mark I. Friedman.
Monell Chemical Senses Center, Philadelphia, PA 19104
APStracts 2:0305R, 1995.
Administration of fat directly into the gastrointestinal tract of rats
produces a rapid and often substantial reduction of feeding behavior.
This contrasts with the normal consumption of a fat meal, which
produces little change in subsequent food intake. To determine
whether procedural differences account for this discrepancy, we
examined the satiating effect of ingested fat on food intake of rats
maintained under feeding conditions similar to those employed in
studies involving gastrointestinal delivery of fat (i.e., food
deprivation, liquid diet). Ingestion of 1.5?ml corn oil had no effect
on subsequent liquid diet intake until 90 min after oil ingestion.
When rats ingested oil 4?h before access to the liquid diet, to allow
time for additional gastrointestinal clearance, liquid diet intake
was reduced by 13% in the first 30?min of access. These findings
indicate that ingested fat decreases short-term intake slightly, but
only if time is allowed for postabsorptive delivery. The results
question the physiological significance of the marked suppression of
food intake observed in response to administration of fat directly
into the gastrointestinal tract.
Received 24 June 1995; accepted in final form 31 October 1995.
APS Manuscript Number R395-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 30 November 95