Activation of sympathetic outflow by recombinant human interleukin
-1[beta] in conscious rats.
Kannan, H., Y. Tanaka, T. Kunitake, Y. Ueta, Y. Hayashida, and H.
Yamashita.
Department of Physiology, Miyazaki Medical College, Kiyotake,
Miyazaki-gun, Miyazaki 889-16, Department of Physiology and
Department of Systems Physiology, University of Occupational and
Environmental Health, Iseigaoka, Yahatanishiku, Kitakyushu 807,
Japan
APStracts 2:0244R, 1995.
The present study was undertaken to determine the effects of
interleukin 1[beta]-(IL-1[beta]) on renal sympathetic nerve activity
(RSNA), arterial blood pressure (AP), heart rate (HR), and body
temperature in conscious rats. Either intravenous (i.v.) or
intracerebroventricular (i.c.v.) administration of IL-1[beta]
elicited increases in AP, HR and RSNA accompanied by a rise in body
temperature. The maximum changes in AP, HR and RSNA occurred 10-15
min after i.v. injection of IL-1[beta] (100 ng), and 20-25 min after
i.c.v. injection (5 ng). The responses induced by the i.v. and i.c.v.
injections lasted for about 15-30 min and did not appear when the
animals were pretreated with the cyclooxygenase inhibitor,
indomethacin (i.v., 10 mg/kg). Moreover, i.c.v. injection of
prostaglandin E2 (1 [mu]g) produced responses similar to those
induced by IL-1 but with shorter latency. Plasma noradrenaline and
adrenocorticotrophic hormone concentrations were increased after IL
-1[beta] injection. The results suggested that IL-1[beta] augments
cardiovascular and sympathetic outflow through the central action of
prostaglandin E2 in conscious rats.
Received 30 November 1993; accepted in final form 14 August 1995.
APS Manuscript Number R649-3.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.