Inhibition of sucrose intake by continuous celiac, superior
mesenteric, and intravenous cholecystokinin infusions.
Cox, James E., Steven M. McCown, Jonathan M. Bridges, and William J.
Tyler.
Department of Psychology, University of Alabama at Birmingham,
Birmingham, AL 35294
APStracts 2:0249R, 1995.
Cox, James E., Steven M. Mccown, Jonathan M. Bridges, and William J.
Tyler. Inhibition of sucrose intake by continuous celiac, superior
mesenteric, and intravenous cholecystokinin infusions. Am. J.
Physiol. (Regulatory Integrative Comp. Physiol.). Two experiments
compared the potency of continuous infusions of cholecystokinin
octapeptide (CCK-8) for reducing sucrose intake when administered
into abdominal arteries or the jugular vein. Adult, male Sprague
-Dawley rats received 22 min infusions of saline or several doses of
CCK-8. Sucrose was available for 20 min, beginning 2 min after onset
of infusions. In the first experiment, intraceliac CCK-8 in doses of
50, 125, and 312 ng produced significant reductions in intake, but no
dose affected intake when administered into the jugular vein. In
Experiment 2, only the highest dose, 312 ng, suppressed intake when
infused into the superior mesenteric artery and jugular infusions
were again ineffective. Behavioral observations indicated that
intraarterial CCK-8 had no affect on feeding within the first several
minutes of test meals but accelerated the subsequent decline in
incidence of feeding. These results suggest that receptors involved
in cholecystokinin satiety are widely distributed within the
gastrointestinal tract.
Received 21 June 1995; accepted in final form 16 August 1995.
APS Manuscript Number R379-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.