Ultradian rhythms of autonomic, cardiovascular, and neuroendocrine
systems are related in humans.
Shannahoff-Khalsa, David S., Brian Kennedy, F. Eugene Yates, and
Michael G. Ziegler.
Division of Nephrology, Department of Medicine, University of
California, San Diego, 200 West Arbor Dr., San Diego, CA. 92103-8341,
The Research Group for Mind-Body Dynamics, Institute for Nonlinear
Science (0402), University of California, San Diego, 9500 Gilman Dr.,
La Jolla, CA 92093-0402, The Khalsa Foundation for Medical Science,
P.O. Box 2708, Del Mar, CA. 92014, Medical Monitoring Unit,
Department of Medicine, University of California, Los Angeles, 1950
Sawtelle Blvd, Suite 330, Los Angeles, CA 90025-7014
APStracts 2:0258R, 1995.
Autonomic, cardiovascular and neuroendocrine activities were monitored
for 5-6 hr in ten normal adult resting humans (8 males, 2 females).
The nasal cycle, a measure of lateralized autonomic tone, was
measured at 4 Hertz. Impedance cardiography (BoMed NCCOM3) was used
to measure cardiac output, thoracic fluid index, heart rate, ejection
velocity index, stroke volume, and ventricular ejection time
(averages of 12 heart beats). Systolic, diastolic, and mean arterial
pressures were measured with an automated cuff at 7.5 min intervals.
Separate blood samples were taken every 7.5 min simultaneously from
both arms using indwelling venous catheters. Assays for
adrenocorticotropic hormone, luteinizing hormone, norepinephrine,
epinephrine, and dopamine were performed on samples from each arm.
Time series analysis using the Fast Orthogonal Search method of
Korenberg was used to detect variance structure. Significant spectral
periods were observed in five windows at 220-340, 170-215, 115-145,
70-100, and 40-65 min. The greatest spectral power was observed in
the lower frequencies, but periods at 115-145, 70-100, and 40-65 min
were common across variables. Significant correlation coefficients
for linear regressions of all paired variables in each subject were
observed in 38.87% of the comparisons (subject range, 18.05% -
49.70%) with R > 0.30. These results suggest either that a
common oscillator (the hypothalamus) or that mutually entrained
oscillators regulate these systems.
Received 1 February 1995; accepted in final form 7 September
1995.
APS Manuscript Number R87-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 23 September 1995.