Angiotensin ii regulates nephrogenesis and renal vascular
development.
Tufro-McReddie, A., L. M. Romano, J. M. Harris, L. Ferder, and R. A.
Gomez.
Department of Pediatrics, University of Virginia School of Medicine
and Hospital Israelita, Buenos Aires, Argentina.
APStracts 2:0044F, 1995.
To test the hypothesis that angiotensin II is necessary for normal
embryonic and postnatal kidney development, the effect of angiotensin
receptor blockade or angiotensin-converting enzyme inhibition on
nephrovascular development was studied in newborn Sprague-Dawley rats
and in Rana Catesbeiana tadpoles undergoing pro-metamorphosis.
Blockade of angiotensin II type 1 receptor (AT1) in newborn rats
induced an arrest in nephrovascular maturation and renal growth,
resulting in altered kidney architecture, characterized by fewer,
thicker and shorter afferent arterioles, reduced glomerular size and
number, and tubular dilatation. Inhibition of angiotensin II
generation in tadpoles induced even more marked developmental renal
abnormalities. Blockade of angiotensin II type 2 receptor (AT2) in
newborn rats did not alter renal growth or morphology. Results
indicate that angiotensin II regulates nephrovascular development, a
role that is conserved across species.
Received 21 November 1994; accepted in final form 28 February
1995.
APS Manuscript Number F414-4.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 4 April 1995.