Angiotensin ii-induced structural and functional alterations in the
spontaneously hypertensive rat kidney.
Kost, Curtis K., Jr, William A. Herzer, Ping Li, Mitsuru Notoya, Vinci
Mizuhira, Tadashi Inagami, Edwin K. Jackson.
Center for Clinical Pharmacology, University of Pittsburgh Medical
Center, Pittsburgh, Pennsylvania, U.S.A., Shionogi Research
Laboratories, Shionogi and Company, Osaka, Japan, Department of
Biochemistry, Vanderbilt University School of Medicine, Nashville,
Tennessee, U.S.A.
APStracts 2:0142F, 1995.
The purpose of this study was to compare functional and structural
changes in the kidneys of spontaneously hypertensive (SHR) and
Wistar-Kyoto (WKY) rats during prolonged administration of
angiotensin II. Rats were pretreated with captopril, and the effects
of exogenous angiotensin II (200 ng/kg/min for 7 to 14 days, s.c.) on
renal hemodynamics and renal vascular structure were examined.
Angiotensin II induced significant reductions of renal blood flow and
glomerular filtration, and increases of renal vascular resistance in
SHR but not WKY. Furthermore, angiotensin II induced an increase of
the media/lumen ratio in the interlobular arteries (0.33+/-.02 to
0.56+/-.02) and arcuate arteries (0.27+/-.02 to 0.53+/-.07) of SHR
without significantly altering the media/lumen ratio in the
interlobular arteries (0.34+/-.03 to 0.34+/-.02) and arcuate arteries
(0.30+/-.02 to 0.36+/-.05) of WKY (two-factor ANOVA strain x
treatment; p=0.0002 for interlobular arteries and p=.0319 for arcuate
arteries). Results from this study indicate that the SHR kidney is
more responsive than the WKY kidney to the functional and structural
effects of prolonged angiotensin II infusion.
Received 14 December 1994; accepted in final form 7 August 1995.
APS Manuscript Number F441-4.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 14 August 1995.