Multiple mechanisms of receptor/g protein signaling specificity
.
Raymond, John R.
Department of Medicine, Division of Nephrology, at Duke University
and Veterans Affairs Medical Center, Durham, N.C. 27710
APStracts 2:0033F, 1995.
The hormone-receptor-G protein complex trandsuces extracellular
information into intracellular signals that ultimately regulate
cellular functions in a highly specific manner. There are hundreds of
receptor types that transduce signals through a relatively limited
repertoire of heterotrimeric G proteins. Linear models of signaling
specificity that require specific and highly selective coupling of
hormone to receptor to G protein have proven inadequate to explain
how highly particular signals are funneled through the G protein
$QUOTbottleneck". Recent studies have uncovered a plethora of
mechanisms which contribute to signaling specificity. This review
focuses on the mechanisms that contribute to specificity in the
interactions of receptors with G proteins.
Received 11 July 1994; accepted in final form 6 March 1995.
APS Manuscript Number F239-4.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 21 March 1995.