Natriuresis caused by increased carotid [na+] after renal
denervation.
Emmeluth, C., K. L. Goetz, C. Drummer, R. Gerzer, W. G. Forssmann, and
P. Bie.
Department of Medical Physiology, University of Copenhagen,
Blegdamsvej 3, DK-2200 Copenhagen N, Denmark, Kansas City, USA,
Institute of Aerospace Medicine, German Aerospace Research
Estabishment (DLR), D-51140 Cologne, Germany,
Nieders[umlaut]achsiches Institut f[umlaut]ur Peptid-Forschung,
Hannover, Germany, Feodor-Lynen-Str 31, D-30625 Hannover, Germany
APStracts 2:0170F, 1995.
The renal effects of a selective estimated 3 mM increase in the
concentration of Na+ in blood perfusing the brain was investigated in
conscious dogs with surgically denervated kidneys. In split-infusion
experiments the concentra tion of Na+ in carotid plasma was increased
by a bilateral carotid infusion of hypertonic NaCl combined with an
infusion of distilled water into the caval vein. In control
experiments the same load of NaCl and water was administered as an
isotonic solution into the carotid and jugular vessels. Peak rate of
Na+ excretion was significantly higher during split-infusion (156+/
-19 [mu]mol/min) compared to control (89+/-14 [mu]mol/min). Renal
excretion of urodilatin increased in both series. Renal excretion of
endothelin immunoreactivity increased significantly more during
split-infusion (20+/-6 pg/min) than during control (9+/-3 pg/min). It
is concluded that the natriuretic response to minute increases in Na+
concentration of carotid plasma is intact after renal denervation.
Further, endothelin may be involved in the excess excretion observed.
Received 3 April 1995; accepted in final form 11 September 1995.
APS Manuscript Number F110-5.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1995 The American Physiological Society.
Published in APStracts on 31 October 95