The impact of early growth retardation on glucoregulatory control
and insulin action in mature rats.
Holness, Mark J.
Department of Biochemistry, Faculty of Basic Medical Sciences,
Queen Mary and Westfield College, University of London, London E1
4NS, U.K.
APStracts 3:0026E, 1996.
Glucoregulation and insulin action was examined in adult female
progeny of dams fed an 8 % protein diet during gestation and
lactation. Progeny were provided with standard (20 % protein) diet at
weaning (24 days), at which time body weight was reduced by 21 %.
Basal (post-absorptive) endogenous glucose production (Ra) and
glucose utilization by oxidative muscles was decreased in offspring
that had experienced early growth retardation. The glucose
disappearance rate after intravenous glucose and the glucose infusion
rate required to maintain euglycemia during insulin infusion were
both increased (by 35 % and 24 % respectively) by early growth
retardation. Insulin secretion was unimpaired. During euglycemic
-hyperinsulinemic clamp, Ra was suppressed further, and there was a 2
-fold greater increment in the stimulation of whole-body glucose
clearance rate, in the offspring that experienced early growth
retardation. Insulin-stimulated glucose utilization by peripheral
tissues was unaffected.
Received 23 August 1995; accepted in final form 18 January 1996.
APS Manuscript Number E409-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 8 February 96