Somatostatin infusion suppresses gh secretory burst frequency and
mass in normal men.
Calabresi, Emanuela, Eiji Ishikawa, Laura Bartolini, Giuseppe
Delitala, Giuseppe Fanciulli, Osvaldo Oliva, Johannes D Veldhuis, and
Mario Serio.
Department of Clinical Physiopathology, Endocrine Unit, University
of Florence, Italy, Department of Biochemistry Medical College of
Miyazaki, Japan, Department of Hematology and Endocrinology,
Endocrine Unit, University of Sassari, Italy, Department of Internal
Medicine, Division of Endocrinology and Metabolism, National Science
Foundation Center for Biological Timing, Health Sciences Center,
Charlottesville, Virginia
APStracts 3:0036E, 1996.
In attempting to elucidate the neuroendocrine mechanisms that regulate
pulsatile GH secretion, we measured serum GH concentrations by an
ultrasensitive immunofluorometric method in blood collected every 10
minutes for 8 h in 11 young healthy male volunteers (age range 21
-31years) before and during somatostatin administration (SS) (an i.v.
bolus dose of 350 [mu]g followed by a continuous infusion at the rate
of 6 [mu]g/kg/h which increases the circulating SS levels to about
570 pg/ml). Pulsatile GH secretion was analysed using the computer
-assisted pulse detection program Cluster and deconvolution analysis.
The area and frequency of GH peaks were significantly reduced during
SS infusion compared to basal values but detectable pulsatile
episodes were still present .These data suggest that in adult males
SS controls pulsatile GH secretion and can decrease the mass and
frequency of GH secretory bursts.
Received 12 June 1995; accepted in final form 5 January 1996.
APS Manuscript Number E267-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 14 February 96