Carbohydrate ingestion augments skeletal muscle creatine
accumulation during creatine supplementation in man.
Green, A. L., E. Hultman, I. A. Macdonald, D. A. Sewell, and P. L.
Greenhaff.
Department of Physiology and Pharmacology, University Medical
School, Queen's Medical Center, Nottingham NG7 2UH United Kingdom;
and Department of Clinical Chemistry, Karolinska Institute, Huddinge
University Hospital, S-141 86 Huddinge, Sweden
APStracts 3:0130E, 1996.
This study investigated the effect of carbohydrate (CHO) ingestion on
skeletal muscle creatine (Cr) accumulation during Cr supplementation
in humans. Muscle biopsy, urine and plasma samples were obtained from
24 males before and after ingesting 5g of Cr in solution (A) or 5g of
Cr followed, 30 min later, by 93g of simple CHO's in solution (B), 4
times each day, for 5 days. Supplementation resulted in an increase
in muscle PCr, Cr and TCr (sum of PCr and Cr) concentration in groups
A and B, but the increase in TCr in group B was 60% greater than in
group A (P<0.01). There was also a corresponding decrease in
urinary Cr excretion in group B (P<0.001). Creatine
supplementation had no effect on serum insulin concentration, but Cr
and CHO ingestion dramatically elevated insulin concentration
(P<0.001). These findings demonstrate that CHO ingestion
substantially augments muscle Cr accumulation during Cr feeding in
man, which appears to be insulin mediated.
Received 8 April 1996; accepted in final form 25 June 1996.
APS Manuscript Number E171-6.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 25 July 1996