Postprandial leg and splanchnic fatty acid metabolism in non-obese
men and women.
Nguyen, Tu. T., Antonio Hern[acute]andez Mijares, C. Michael Johnson,
Michael D. Jensen.
Endocrine Research Unit and Department of Radiology* Mayo Clinic,
Rochester, MN 55905
APStracts 3:0141E, 1996.
These studies were conducted to determine whether there are gender
specific regional differences in meal triglyceride fatty acid uptake.
Systemic and regional oleate ([3H]oleate) kinetics were measured in 9
non-obese men and 8 women before and at the end of a 6-hour meal
administered as small frequent feedings to achieve steady-state
chylomicronemia. Results: Chylomicron uptake in the splanchnic bed
accounted for 71 +/- 15% of meal triglyceride disappearance in men
and 20 +/- 7% in women (P<0.01), leg chylomicron uptake could
only account for 12 +/- 2 and 8 +/- 4% (P=NS men vs women) of meal
triglyceride disappearance. Meal ingestion suppressed (P<0.05)
systemic and regional FFA release in both men and women. Splanchnic
non-chylomicron triglyceride release and leg non-chylomicron
triglyceride uptake were not significantly different in men and
women. In summary, the largest quantitative difference between men
and women in fatty acid kinetics during meal ingestion is a
substantially greater splanchnic uptake of meal triglyceride fatty
acids in men. This could represent greater meal fatty acid storage in
visceral adipose tissue.
Received 20 February 1996; accepted in final form 15 July 1996.
APS Manuscript Number E87-6.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 25 July 1996