Appetite regulation by carbohydrate: role of blood glucose and
gastrointestinal hormones.
Lavin, J. H., G. Wittert, W. M. Sun, M. Horowitz, J. E. Morley, and N.
W. Read.
Department of Medicine, University of Adelaide, Royal Adelaide
Hospital, Adelaide, Australia 5000, Centre for Human Nutrition,
Northern General Hospital, Sheffield S5 7AU, U.K., St. Louis
University Health Sciences Center, Division of Geriatric Medicine,
1402 S. Grand Blvd, St Louis, Missouri, USA 63104
APStracts 3:0040E, 1996.
To investigate the mechanisms by which intestinal carbohydrate affects
eating behaviour, seven fasted, healthy male volunteers received
intraduodenal infusions of glucose or saline over a 90 minute period
whilst blood glucose levels were matched using intravenous glucose
and saline infusions. A second study examined the effect of
intraduodenal glucose on eating behaviour when the gastrointestinal
hormone response was inhibited by intravenous octreotide. Intravenous
glucose infusion did not affect hunger or satiety. In contrast,
intraduodenal infusion of glucose suppressed hunger, increased
fullness and satiety ratings, reduced energy intake, and resulted in
higher plasma insulin responses compared with the intravenous glucose
infusion. Octreotide abolished the plasma insulin response to
intraduodenal glucose and reversed the changes in ratings and eating
behaviour. This study has shown that the effects of intestinal
glucose on appetite are not mediated via an increase in blood
glucose, but are likely to reflect small intestinal stimulation of
release of either insulin or intestinal incretins.
Received 3 October 1995; accepted in final form 20 February 1996.
APS Manuscript Number E484-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 March 96